Table 2.
Uni- and multivariable survival analysis: Cox’s proportional hazard model for overall survival
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| Gender (male vs female) | 1.08 (0.94–1.26) | 0.33 | ||
| Bismuth type (2 or 3 vs 4) | 0.85 (0.71–1.00) | 0.063 | ||
| Biliary drainage (yes vs no) | 1.08 (0.95–1.13) | 0.41 | ||
| Portal vein embolization (yes vs no) | 1.21 (1.00–1.47) | 0.050 | ||
| Major liver resections (yes vs no) | 0.79 (0.45–1.37) | 0.41 | ||
| Extended liver resections (yes vs no) | 0.82 (0.47–1.43) | 0.50 | ||
| Segment 1 resected (yes vs no) | 0.97 (0.79–1.20) | 0.81 | ||
| Portal vein resection (yes vs no) | 1.19 (1.02–1.40) | 0.028 | ||
| Hepatic artery resection (yes vs no) | 1.62 (1.06–2.49) | 0.025 | ||
| Margins (positive vs negative) | 1.64 (1.39–1.93) | <0.001 | 1.36 (1.10–1.67) | 0.004 |
| N stage (N1 vs N0) | 1.87 (1.59–2.19) | <0.001 | 1.62 (1.32–1.99) | <0.001 |
| Perineural invasion (yes vs no) | 1.66 (1.32–2.08) | <0.001 | 1.53 (1.15–2.04) | 0.004 |
| Differentiation grade (poor vs well/moderately) | 1.39 (1.22–1.59) | <0.001 | 1.25 (1.05–1.47) | 0.009 |
HR, hazard ratio; CI, confidence interval