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. 2021 May 14;39(10):3789–3797. doi: 10.1007/s00345-021-03723-4

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Expression of miR-205, miR-3195, miR-3687, and miR-4417 in human prostate tissue and their association with CRPC. MiRNA expression analysis was performed by stem-loop RT-qPCR analysis. The results were normalized to the weighted average of miR-26a, miR-107 and RNU6 levels. The median expression and the standard deviation are shown; outliers are indicated by open circles and asterisks. MiR-205 a is significantly downregulated, whilst miR-3195 b, miR-3687 c and miR-4417 d are significantly upregulated in CRPC tissue compared to primary PCa tissue. BPH, benign prostate hyperplasia; LG, low grade prostate cancer; HG, high grade prostate cancer; CRPC, castration-resistant prostate cancer. e, f Receiver operating characteristic curve (ROC) analysis was performed using miRNA expression data from the validation set (n = 83), comparing the ability of miR-3195, miR-3687, miR-4417 alone and combinations of miR-3195 and miR-3687, and of miR-205, miR-3195 and miR-4417 to identify men with CRPC. Areas under the curve (AUC) are shown (*p < 0.01)