Fig. 2.

DNA sequence of the translation start region of exon 1 of SOD1 in Markiesje dogs with and without paroxysmal dyskinesia. In the affected dog, the first of two G-residues is replaced by the trinucleotide CAC. The arrows indicate unaltered A- and G-residues. The mutation leads to a frameshift at the 4th codon of the gene. The codons are indicated by alternating lines with the encoded amino acid in one letter code. *Denotes the TGA stop codon