FIGURE 2.

Micro‐structural changes in the orientation and integrity in AD compared to CN across the whole brain white matter. Tract‐Based Spatial Statistics white matter analysis showing a pattern of orientational changes (i.e., splay, bend, twist, and total distortion) and classical metrics (i.e., FA and MD) overlaid on the white matter skeleton (green) in individuals with Alzheimer's disease compared to cognitive normal individuals (p < .05, corrected for multiple comparisons). Blue is for the decrease, and Red is for the increase. AD, Alzheimer's disease; CN, cognitively normal; FA, fractional anisotropy; MD, mean diffusivity