. 2021 Aug 25;42(16):5357–5373. doi: 10.1002/hbm.25624

TABLE 4.

Changes in functional connectivity in whole brain analysis in Model EA6

Seed	Covariates	Clusterwise ^a			Voxelwise at local maximum
		FWE‐corr. P	Cluster size	Z score	FWE‐corr. P	MNI coordinates			Hem	Anatomical region ^b
		FWE‐corr. P	Cluster size	Z score	FWE‐corr. P	X	Y	Z	Hem	Anatomical region ^b
Average logmFD (increase)
NAcc (CC)	Age, sex	0.005	126	1.576	0.053	9	−15	60	R	Posterior‐medial frontal
					0.266	12	−24	63	R	Posterior‐medial frontal
					0.383	9	−18	69	R	Posterior‐medial frontal
Average logmFD (increase)
NAcc (GSR)	Age, sex	0.027	54	1.770	0.138	9	−15	60	R	Posterior‐medial frontal
					0.406	9	−6	72	R	Posterior‐medial frontal
					0.898	0	−15	60	L	Posterior‐medial frontal

Abbreviations: CC, preprocessing with AROMA + CC; FWE‐corr., family‐wise error corrected; GSR, preprocessing with AROMA + CC + GSR; Hem, hemisphere; L, left; MNI (Montreal Neurological Institute) coordinates of primary peak location: X, sagittal; Y, coronal; Z, axial; R, right.

^{^a}

To identify significant clusters, we applied a cluster size threshold with p < .001 determined by Wild Bootstrap of 1,000 samples.

^{^b}

Connectivity with maximum three voxels that mark local maxima within the respective cluster; more detailed description of anatomical regions that are assigned to overall clusters and corresponding probability in Supporting Information.