Table 3.

Univariable Cox proportional hazard model analysis of prognostic factors for late local recurrences

	Patients	Local recurrence	%	HR	95% CI	p value	p value b
Age (year)
< 64	183	16	8.7	Reference
≥ 64	194	18	9.3	1.2	0.6–2.4	0.58	0.58
Sex
Male	214	21	9.8	Reference
Female	163	13	8.0	0.8	0.4–1.6	0.48	0.48
Depth
Superficial	175	16	9.1	Reference
Deep	196	18	9.2	0.8	0.4–1.7	0.63	0.63
Not available	6	0
Location
Lower extremity	233	24	10	Reference
Upper extremity	100	6	6.0	0.6	0.2–1.4	0.25
Trunk	44	4	9.1	0.9	0.3–2.5	0.82	0.48
Size (cm)
< 5	144	10	6.9	Reference
≥ 5	229	22	9.6	1.3	0.6–2.8	0.46	0.45
Not available (cm)	4	2
< 8	244	16	6.6	Reference
≥ 8	129	16	12	1.9	0.9–3.7	0.08	0.08
Not available	4	2
Malignancy grade
Low-grade	81	5	6.2	Reference
High-grade	282	28	10	1.6	0.6–4.2	0.32	0.30
Not available	14	1
Vascular invasion
No	273	21	7.7	Reference
Yes	38	4	11	1.4	0.5–4	0.55	0.57
Not available	66	9
Necrosis
No	157	13	8.3	Reference
Yes	167	14	8.4	1.1	0.5–2.3	0.81	0.81
Not available	53	7
Growth pattern
Pushing	20	2	10	Reference
Infiltrative	88	7	8.0	0.8	0.2–3.9	0.76	0.76
Not available	269	25
Histology
UPS	78	10	13	Reference
Leiomyosarcoma	81	4	4.9	0.4	0.1–1.4	0.16
Liposarcoma	47	3	6.4	0.5	0.1–1.9	0.31
MPNST	18	3	17	1.0	0.3–4	0.90
Myxofibrosarcoma	68	8	12	0.8	0.5–3.2	0.63
Synovial sarcoma	19	0	0	–*
Other	66	6	9.1	0.7	0.3–2.1	0.60	0.15
Surgical procedure a
Local excision	321	30	9.3	Reference
Amputation	12	0	0	–
Final surgical margin
R0 wide	252	13	5.2	Reference
R0 marginal	109	16	15	3.3	1.6–6.8	0.001
R1	15	4	27	5.4	1.8–16.6	0.003	0.001
Not available	1	1
Radiotherapy
No	248	18	7.3	Reference
Yes	129	16	12	2.3	1.2–4.6	0.015	0.017
Chemotherapy
No	332	30	9.0	Reference
Yes	45	4	8.9	1.4	0.5–4.0	0.55	0.56

UPS undifferentiated pleomorphic sarcoma; MPNST malignant peripheral nerve sheath tumor

^aNot applicable to the 44 patients with tumors located to the trunk wall

^bOverall likelihood ratio test