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. 2021 Oct 15;11:20511. doi: 10.1038/s41598-021-99352-3

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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AD survival curves and gene expression trajectories with age. We analyzed the expression of each AD risk gene to see how it may affect the survival of AD patients with low and high expression levels and how it trends with age in AD patients and normal controls. (A) The heatmap of P-values of Kaplan–Meier survival analyses and gene expression trend tests across four brain regions (see Methods). Nine AD risk genes with at least one P-value less than 0.05 (labeled) are included in the heatmap. This figure includes AD survival curves and gene expression trajectories with age for three genes with P < 0.05: (B) LAMTOR4 in the brain region BM10, (C) NRG3 in the brain region BM22, and (D) GRB2 in the brain region BM36. See Supplementary Fig. S10 for plots of other significant results.