Table 1.

Summary of effects on DPRs with eif-2D/eIF2D decrease.

Species	G4C2 repeats	eIF2D	Poly-GA	Poly-GP	Poly-GR
C. elegans	Monocistronic construct, 75 G4C2	Null allele	↓↓	↓	NS
NSC34 cells	Monocistronic construct, 75 G4C2	KD	↓↓	NS	NS
HEK293 cells	Bicistronic construct, 75 G4C2	KD	↓↓	↓↓	↓↓
iPSC-derived motor neurons	Endogenous C9ORF72 locus, >24 G4C2	KD	ND	NS	NS

↓↓: >50% decrease.

↓: <50% decrease.

KD knockdown, NS not significant, ND not detected.