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. 2021 Oct 15;11:20556. doi: 10.1038/s41598-021-00159-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Podocyte-specific Crb2 knockout mice develop FSGS at 6 months of age. (a) Massive albuminuria was observed at 6 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Microhematuria was observed at 6 months of age in Crb2^fl/flpod-Cre^Tg/+ mice compared to Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. (b) The blood urea nitrogen and serum creatinine levels were comparable among the three groups at 6 months of age. (c) The sclerotic indices in Crb2^fl/flpod-Cre^Tg/+ mice were significantly higher than those in Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Scale bars 50 μm. (d) The fibrotic indices in Crb2^fl/flpod-Cre^Tg/+ mice were significantly higher than those in Crb2^+/+pod-Cre^Tg/+ or Crb2^fl/fl mice. Scale bars 100 μm. Data are presented as mean ± SD. Statistical analysis by one-way analysis of variance, followed by Scheffe's multiple comparison test; n = 6 in each group. ***P < 0.001, ****P < 0.0001.