Table 1.
Clinical and pathological features of CRC samples. Table describes the distribution of human colorectal tumors collected at University of Rome "Sapienza", according to high/low levels of p27 respect to the expression average (52% of neoplastic cells) and to the indicated clinico-pathological features. p-value was calculated using Fisher’s exact test.
| Clinic-pathological features of CRC tumors | Low p27 | High p27 | p-value | |
|---|---|---|---|---|
| (n = 86) | (n = 115) | |||
| Age | Average (range) | 65 (23–86) | 67 (32–87) | 0.419 |
| Sex | Female | 36 (42%) | 40 (35%) | 0.305 |
| Male | 50 (58%) | 75 (65%) | ||
| Cancer Site | Primary | 77 (90%) | 94 (82%) | 0.124 |
| Metastasis | 9 (10%) | 21 (18%) | ||
| Grading | 1–2 | 20 (23%) | 33 (28%) | 0.201 |
| 3–4 | 56 (65%) | 60 (52%) | ||
| Stage | I–II | 15 (17%) | 10 (9%) | 0.094 |
| III–IV | 70 (81%) | 96 (83%) | ||
| RAS | Mutated | 57 (66%) | 64 (56%) | 0.279 |
| Wild type | 29 (34%) | 45 (39%) | ||
| BRAF | Mutated | 3 (3%) | 7 (6%) | 0.219 |
| Wild type | 38 (44%) | 37 (32%) | ||
| Microsatellite | Instable | 4 (5%) | 1 (<1%) | 0.133 |
| Stable | 15 (17%) | 19 (17%) | ||
| Histotype | Mucinous | 42 (49%) | 19 (17%) | 0.000001 |
| Non-mucinous | 44 (51%) | 96 (83%) | ||
| Tumor Edge | Pushing | 5 (6%) | 18 (16%) | 0.941 |
| Infiltrative | 7 (8%) | 24 (21%) | ||
| Neoadjuvant | No | 74 (86%) | 91 (79%) | 0.987 |
| Yes | 5 (6%) | 9 (8%) |