Fig. 3.

The overexpression of E-selectin in IR-induced injured kidney and the renal targeted distribution of NPs with SA modification. (A) Representative immunohistochemical images of E-selectin in kidneys of healthy and IRI mice. (B and C) Western blot analysis of E-selectin protein expression in kidneys of healthy and IRI mice. (D) The fluorescent signal image of major organs of IRI mice treated with ICG-labeled NPs and SA-NPs at 6 h after injection. (E) The fluorescent signal image of kidneys of IRI mice treated with ICG-labeled NPs and SA-NPs at different times. (F) The distribution of SA-NPs, NPs and DXM in IRI mice at 6 and 12 h after injection at a dose of 1.2 mg/kg DXM, respectively. (n = 3) (Reproduced with permission from [52]. Copyright 2017 Elsevier).