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The long-circulation performance of RM-LIP in vitro and in vivo. (A) Cellular uptake of different liposomes in murine macrophage cells-RAW 264.7 under a fluorescence microscope. scale bar, 100 µm; (B) Flow cytometry results of cellular uptake in RAW264.7; (C) Quantification of the mean fluorescence intensity of the flow cytometry histograms (n = 3, **P< 0.005, ***P< 0.001); (D) Pharmacokinetics of minocycline-loading liposomes in rats for 24 h after administration (n = 6).
