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. 2021 Mar 23;16(4):483–493. doi: 10.1016/j.ajps.2021.03.001

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© 2021 Shenyang Pharmaceutical University. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 3 — (A) The synthesis scheme and ¹H NMR (DMSO‑d6) spectra of Cy5-Ac2–26. (B) Representative biodistribution images of arthritic rats after the intravenous injection of free Cy5-Ac2–26 peptides (Free) and Cy5-ADNPs at different time points. (C) Fluorescent signal comparison in paws segregated of arthritic rats after the intravenous injection of free Cy5-Ac2–26 peptides and Cy5-ADNPs at 2, 6 and 24 h, respectively. These results were calculated by Image J software. Results were shown as mean ± SD (n = 3). (D) Pharmacokinetics profiles after the intravenously injection of free Cy5-Ac2–26 peptides and Cy5-ADNPs at the dose of 0.5 mg/kg. Results were shown as mean ± SD (n = 6).