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. 2021 Mar 23;16(4):483–493. doi: 10.1016/j.ajps.2021.03.001

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© 2021 Shenyang Pharmaceutical University. Published by Elsevier B.V.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig 4 — In vivo therapeutic efficacy of ADNPs in AIA rats. (A) Overall experimental schedule for the treatment of arthritic rats. (B) Representative images of the hind paws after the treatment with PBS, free Ac2–26 peptides and ADNPs for 14 d, respectively. The paw thickness (C) and AUC score (D) after the treatment of PBS, free Ac2–26 peptides and ADNPs. The swelling degree score (E) and AUC score (F) after the treatment of PBS, free Ac2–26 peptides and ADNPs. Results were shown as mean ± SD (n = 7). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.