Table 3. Comparison of mean ± SD values for some tapentadol pharmacokinetic variables in dogs and cats.
| Species | Route and dose | Parameters (units) | Mean ± SD values | References |
|---|---|---|---|---|
| Dogs | IV (50 mg/dog) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (min) Cmax (ng/ml) |
ND 5,917–7,236 59.8–116.6 ND ND |
[97] |
| IV (30 mg/kg) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (h) Cmax (ng/ml) |
ND ND ND 3.5 ± 1.2 31.0 ± 7.5 |
[95] | |
| IV (20 mg/kg) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (h) Cmax (ng/ml) |
ND ND ND 2.4 ± 1.2 19.7 ± 5.5 |
[95] | |
| IV (10 mg/kg) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (h) Cmax (ng/ml) |
ND ND ND 2.7 ± 0.9 10.2 ± 1.8 |
[95] | |
| Oral (200 mg/dog) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (min) Cmax (ng/ml) |
4.4 ± 2.3 7,024–55,358 1,138–2,384 47.5 ± 6.1 240–3,640 |
[97] | |
| Cats | IV (5 mg/kg) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (h) Cmax (ng/ml) |
ND 8.79 ± 1.97 35.60 ± 7.05 ND ND |
[99] |
| IM (5 mg/kg) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (h) Cmax (ng/ml) |
93.93 ± 9.91 7.53 ± 2.95 37.85 ± 5.68 0.25 ± 0.26 1,406 ± 779 |
[99] | |
| SC (5 mg/kg) |
F% Vd (ml/kg) Cl (ml/min/kg) Tmax (h) Cmax (ng/ml) |
90.01 ± 6.52 7.06 ± 2.10 40.13 ± 9.97 0.63 ± 0.31 906 ± 356 |
[99] |
F% = bioavailability, ND = not determined, Vd = apparent volumen of distribution at steady-state, Cl = clearance, Tmax = time of maximum plasma concentration, Cmax = maximum plasma concentration.