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. 2021 Sep 19;8(3):404–422. doi: 10.5455/javar.2021.h529

Table 7. Clinical signs of serotonin syndrome in companion animals [115,117].

Body system Clinical signs
Cardiovascular Tachycardia, bradycardia, arrhythmia, hypertension
Respiratory Tachypnea
Nervous system Sedation, lethargy, hyperexcitability, temporary blindness, nystagmus
Mental status Confusion, agitation, excitement, vocalizations, aggression, coma
Neuromuscular Hyperreflexia, muscle spasms and hyperthermia, trembling, rigidity, convulsions, recumbency, weakness, hyperesthesia
Gastrointestinal Hypersalivation, nausea, vomiting, diarrhea, abdominal pain
Metabolic Fever or hyperthermia with diaphoresis