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. 2021 Oct 16;24(11):103295. doi: 10.1016/j.isci.2021.103295

Figure 7.

Figure 7

The in vivo elimination of NIH/3T3 cells expressing SARS-CoV-2 S1

(A) Images of NIH/3T3-S1 cells in mice. NIH/3T3-S1 cells express luciferase and the presence of luminescence after D-luciferin injection indicates the presence of NIH/3T3-S1 cells. A mixture of 2 × 106 NIH/3T3-S1 cells and 4 × 106 CR3014-28Z or CR3022-28Z CAR-Ts were injected into NOD-SCID IL2Rγnullmice through the intraperitoneal route. Twenty-four hours later, D-luciferin was injected and bioluminescence images were acquired. 3 mice are shown out of 8 mice per group in total.

(B) Histogram showing the significant reduction of NIH/3T3-S1 cells in vivo by CR3022-8a-28Z but not by CR3014-28Z CAR-T cells. Data are shown as mean ± SD of 8 mice. ∗p < 0.05, ∗∗∗p < 0.001 (compared with untreated group by one-way ANOVA). This experiment was repeated twice.