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. 2021 Oct 16;21:537. doi: 10.1186/s12935-021-02245-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — SNHG12 up-regulated the transcription of FAM83B by binding to the RNA-binding protein HuR. A The binding probability between HuR and FAM83B was predicted using RNA–Protein Interaction Prediction (RPISeq) database. B The binding between HuR and FAM83B was analyzed by RIP assay. C–E The expression of FAM83B in gastric adenocarcinoma was predicted by the Starbase, UALCAN, and GEPIA database. F, G The mRNA level of FAM83B in GC tissues and cells was detected by RT-qPCR. H Relevance between SNHG12 and FAM83B by Pearson. I, J mRNA level and half-life period of FAM83B in AGS cells were detected by RT-qPCR. The experiment was repeated 3 times independently. Data in panels A, B, G, I were presented as mean ± standard deviation. Comparison between data in panel F was analyzed using the t-test. Comparisons among data in panels G/I were analyzed using one-way ANOVA and comparison among data panel J was analyzed using two-way ANOVA followed by Tukey's multiple comparisons test. **p < 0.01. sh-NC: NC shRNA: sh-SNHG12: SNHG12 shRNA. pc-NC: NC pcDNA; pc-HuR: HuR pcDNA