Fig. 14.

Synergistic effect of “metal-oxidase” cascade catalytic system and immunotherapy. A1 Schematic illustration of the smart biomimetic nanoplatform for antitumor “metal-oxidase” and immunometabolism normalization based on the ROS-ferroptosis-glycolysis regulation. A2 Measurement of GPX4, PKM2 and HK2 expression by western blot. A3 ELISA analysis of IL-6 and IFN-γ levels and the relative quantification results of T cells of 4T1 tumor bearing mice after various treatments. The

Reproduced with permission from Ref [19], copyright © 2021, Elsevier. B1 Schematic illustration of fabrication and mechanism of PEGylated CMS@GOx for combined therapy. B2 Quantification of CD80 and CD86 expression on the surface of human bone-marrow-derived DCs after different treatment by flow cytometry. B3 Growth curves of primary tumor volume and distant tumor volume in Balb/c mice with different treatments. Reproduced with permission from Ref [136], copyright © 2019 WILEY–VCH