Fig. 3.

Manganese mediates the Fenton reaction to trigger CDT. A1 Schematic illustrating the application of MS@MnO₂ NPs for MRI-monitored chemo-chemodynamic combination therapy. A2 Viability of U87MG cells after 24 h of different treatments. And viability of U87MG cells after 24 h of different treatments. And H&E-stained images of tumour sections from different groups.

Reproduced with permission from Ref [39], copyright © 2018 WILEY–VCH. B1 Illustration of the synthetic process of MCDION-Se. And the cascade reaction of MCDION-Se in the intracellular environment. B2 The higher the degree of acidity the stronger the catalytic reaction. B3 Relevant in vitro experiments and in vivo experiments demonstrated the efficacy and safety of MCDION-Se. Reproduced with permission from Ref [40], copyright © 2019 Elsevier. C1 Schematic diagram and efficacy of LCN@Mn-BA nanoparticles for anti-tumor. C2 In vivo experiments in mice demonstrated LCN@Mn-BA can effectively inhibit tumor growth with good biosafety. Reproduced with permission from Ref [38], copyright © 2020 Elsevier