Fig. 4.

Glucose oxidase-mediated starvation therapy. A1 Schematic illustration of the mCGP nanoparticles for cancer targeting starvation therapy and PDT. A2 The dark and light toxicities of mCGP against 4T1 cells by MTT assay under 21% O₂ or 2% O₂. A3 The anticancer efficiency of mCGP in vivo.

Reproduced with permission from Ref [56], copyright © 2017, American Chemical Society. B1 Illustration of GOx-induced starvation for enhanced low-temperature PTT in a hypoxic TME. B2 Representative Western blotting of HSP 90 and HSP 70 expression under different conditions. B3 In vivo experiments in mice, the nanoparticles were able to effectively inhibit tumors and prolong mouse survival time. Reproduced with permission from Ref [53], copyright © 2018, American Chemical Society