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. 2021 Oct 16;19:325. doi: 10.1186/s12951-021-01074-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — Synergistic effect of "copper-GOx" cascade catalytic system in tumor therapy. A1 Scheme of synthetic process and therapeutic mechanism of HMSN-Cu-GOD. A2 Cytotoxicity of HMSN-Cu-GOD treatment for MCF-7 cells after 24 h of incubation. A3 Body weight and tumor volumes change during 15 days of observation periods in different groups subjected to various treatments.

Reproduced with permission from Ref [89], copyright © 2020 Elsevier. B1 Schematic illustration of the main synthesis procedures and antitumor mechanism of PCN-224(Cu)-GOx@MnO₂ nMOFs. B2 Cell viability with different treatment. B3 In vivo anticancer efficacy of PCN-224(Cu)-GOx@MnO₂ nMOFs. Reproduced with permission from Ref [90], copyright © 2020, American Chemical Society