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. 2021 Oct 16;19:325. doi: 10.1186/s12951-021-01074-1

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 9 — The synergistic anti-tumor system of "metal-oxidase" system combined with chemotherapy. A1 Diagram of how Fe/G@R-NRs is synthesized and how it is in an acidic environment at disassembly further and induces multiple antitumor responses. A2 Cytotoxicity against A549 cells at various CPT-equivalent concentrations. A3 Time-dependent A549 tumor growth profiles. The arrows indicate the injection time. Mice body weight change over the time during the treatment. The survival curve of A549 tumor-bearing mice after various treatments.

Reproduced with permission from Ref [103], copyright © 2019, American Chemical Society. (B) B1 schematic illustration of GOx-MnCaP-DOX applied for MRI-monitored cooperative cancer therapy. B2 Average body weight and relative tumor volume in different groups subjected to various treatments. And H&E staining images of tumor tissues excised from the mice at day 14. Reproduced with permission from Ref [105], copyright © 2019, American Chemical Society