Table 3.

Cox Regression Analysis of Overall Survival (OS) and Progression-Free Survival (PFS) in HCC Patients from TCGA Database

	Overall Survival				Relapse-Free Survival
Variable	Univariate Cox		Multivariate Cox		Univariate Cox		Multivariate Cox
	HR	P	HR	P	HR	P	HR	P
Age (year)	1.012 (0.998–1.026)	0.085	1.034 (1.012–1.057)	0.002	1.000 (0.990–1.010)	0.964
Sex (male vs female)	0.819 (0.573–1.169)	0.271			0.926 (0.701–1.223)	0.587
Race
Asian	1 (Reference)				1 (Reference)
Black	1.550 (0.660–3.641)	0.315			0.955 (0.480–1.898)	0.895
White	1.321 (0.906–1.926)	0.148			1.228 (0.931–1.622)	0.147
AFP (up vs normal)	1.777 (1.085–2.909)	0.022	1.506 (0.861–2.634)	0.151	1.519 (1.088–2.120)	0.014	1.495 (1.042–2.144)	0.029
Tumor stage
I	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
II	1.497 (0.915–2.450)	0.108	0.843 (0.400–1.779)	0.654	1.703 (1.205–2.408)	0.003	1.603 (0.999–2.573)	0.050
III	2.710 (1.772–4.146)	<0.001	1.761 (0.939–3.302)	0.078	2.390 (1.720–3.321)	<0.001	1.967 (1.214–3.187)	0.006
IV	5.573 (1.717–18.090)	0.004	7.056 (2.029–24.546)	0.002	4.971 (1.801–13.720)	0.002	4.002 (1.215–13.180)	0.023
Tumor grade
G1	1 (Reference)				1 (Reference)
G2	1.176 (0.694–1.992)	0.547			1.148 (0.771–1.709)	0.498
G3	1.208 (0.696–2.097)	0.501			1.246 (0.824–1.885)	0.297
G4	1.407 (0.474–4.175)	0.539			1.124 (0.469–2.694)	0.793
Vascular invasion
None	1 (Reference)		1 (Reference)		1 (Reference)		1 (Reference)
Micro	1.264 (0.805–1.984)	0.310	1.459 (0.759–2.804)	0.257	1.436 (1.041–1.981)	0.027	1.115 (0.720–1.726)	0.627
Macro	2.259 (1.072–4.758)	0.032	3.759 (1.578–8.957)	0.003	2.183 (1.197–3.981)	0.011	2.290 (1.125–4.664)	0.022
KLKB1 expression	0.826 (0.721–0.946)	0.006	0.784 (0.627–0.979)	0.032	0.889 (0.797–0.991)	0.034	0.913 (0.783–1.064)	0.242