|
Author
|
Calcium sulphate derivative /dose
|
Total joints
|
Knees (n)
|
Hips (n)
|
Other joints
|
Hypercalcaemia
|
Calcium value
|
Transient Hypercalcemia
|
Long-standing Hypercalcemia
|
Management
|
Space Calcium sulphate used in
|
|
Sandiford [8]
|
Stimulan Mean volume (25ml) Range of 20-40ml
|
29
|
0
|
29
|
0
|
Not specified
|
Mean preoperative corrected serum calcium level was 2.5mmol/l. Day 1 post surgery was 2.7 mmol/l. For week 1, week 2 and week 6 the mean values were 2.7 mmol/l, 2.7 mmol/l and 2.4 mmol/l respectively.
|
Not specified
|
0
|
No treatment
|
Intracapsular compartment of the hip
|
|
Kallala and Haddad [6]
|
Stimulan Maximum of 40 cc
|
15
|
6
|
9
|
0
|
3
|
Not stated
|
3
|
0
|
1 patient developed symptoms and required rehydration with four litres of IV 0.9% saline over 24-hours and IV bisphosphonates (4 mg of Zoledronic acid over 15 minutes)
|
Around the hip and knee joint
|
|
Kallal et al [7]
|
Stimulan mean of 23.39 cc (5 to 80)
|
755
|
456
|
299
|
0
|
41
|
the mean levels were 11.7 mg/dl (10.8 to 14.9) the levels returned to normal at a maximum of five days postoperatively.
|
41
|
0
|
two patients in the revision THA group developed symptoms and were treated with one iv dose of bisphosphonate and 0.9% saline.
|
For patients undergoing knee surgery, the beads were placed in the medial and lateral gutters. For those under-going hip surgery, they were placed deeply, inferior to the acetabulum and around the proximal femur.
|
|
McPherson et al [5]
|
Stimulan ranged Volume 5cc to 70cc in hip cases and 5cc to 50cc in knee
|
250
|
142
|
108
|
0
|
0
|
n/a
|
0
|
0
|
n/a
|
For knee cases, the Stimulan beads were delivered along the medial and lateral gutters of the knee For hip cases, the Stimulan antibiotics beads were delivered into the deep hip space inferior to the acetabulum and around the proximal femur.
|
