Table 1.
Characteristics of studies included in the meta-analysis
| Author and date of Publication | N ()* | Patient characteristics | Study design | Blinding status | Amount and type of alcohol consumed | AHI- Baseline (SD) | AHI-After alcohol consumption (SD) | Mean oxygen saturation in sleep-Baseline (SD) | Mean oxygen saturation in sleep-After alcohol consumption (SD) |
|---|---|---|---|---|---|---|---|---|---|
| Arnedt-2017 | 93 | Healthy adults | Cross-over randomized clinical trial | Double-blind | 1.2 g/kg for men and 1.1 g/kg for women | 2.59(3.17) | 2.84(4.23) | 96.88 (1.08) | 96.14 (1.05) |
| Block-1986 | 78 | Healthy subjects | Cross-over randomized clinical trial | None | 1 ml/kg vodka | Not available | Not available | 95.32 (6.78) | 95.37 (5.06) |
| Block-1987 | 17 (34) | Healthy subjects | Cross-over randomized clinical trial | None | 1.1 ml/kg vodka/0.95 scotch | Not available | Not available | 95.9 (1.3) | 95.7 (1.4) |
| Brander-1992 | 9 | Male patients with advanced COPD | Cross-over randomized clinical trial | None | 0.5 g/Kg | Not available | Not available | 89.1 (1.6) | 88.4 (2) |
| Collop-1994 | 13 | Men with OSA | Cross-over clinical trial | None | 1 ml/kg of 100-proof vodka | 9.6 (5.3) | 20.2 (16) | 91.8 (1) | 91.8 (1) |
| Herzog-2004 | 21 (42) | 8 snorers and 13 non-snorers | Cross-over randomized clinical trial | None | Blood alcohol concentrations (BAC) of 0.5 and 0.8%. | 2.76 (2.18) | 5.4 (4.78) | 95.86 (0.25) | 95.23 (0.48) |
| Holmendahl-2015 | 26 | Patients with COPD | Cross-over randomized clinical trial | None | 0.5ml/kg of 96% vol ethanol | 9.7 (10.2) | 10.4 (16.4) | 93.4 (4.7) | 93.2 (5.7) |
| Izumi-2005 | 23 | Healthy men | Cross-over randomized clinical trial | None | 0.7 g/kg varied | 2.9 (4.5) | 7.8 (8.2) | 95.7 (1.3) | 95.2 (1.3) |
| Kido-2016 | 18 | Healthy subjects | Cross-over randomized clinical trial | None | 40 g total- traditional Japanese alcohol beverages | 2 (1) | 5.6 (4.8) | Not available | Not available |
| Reimann-2010 | 20 (40) | 20 men (10 snorers and 10 non-snorers) | Cross-over randomized clinical trial | None | Blood alcohol concentrations (BAC) of 0.5 and 0.8%. | 3.15 (2.98) | 6 (6.65) | 95.4 (3.76) | 94.57 (6.05) |
| Scanlan-2000 | 21 | Men- habitual snorers | Cross-over randomized clinical trial | None | 0.5 g/kg White wine | 7.1 (1.9) | 9.7 (2.1) | 95.9 (0.4) | 95.3 (0.4) |
| Scrima-1989 | 62 (186) | 30 snorers and 32 non-snorers | Cross-over randomized clinical trial | Double Blind | 0.325, 0.65, and 0.8 1 g /kg | 13.32 (9.72) | 14.26 (11) | 95.95 (2.6) | 95.34 (3.16) |
| Taasan-1981 | 20 | Healthy men | Cross-over randomized clinical trial | Blinding attempted but broken | 2 g/kg vodka | 0.7 (0.75) | 2.33 (1) | Not available | Not available |
| Teschler-1996 | 14 | Men with OSA | Cross-over randomized clinical trial | Investigators blinded to alcohol status | 0.5 g/kg vodka | 44.1 (7.2) | 50.6 (0.8) | Not available | Not available |
BMI ¼ body mass index, kg/m2; SpO2 ¼ oxyhemoglobin saturation; AHI ¼ apnea-hypopnea index; OSA ¼ Obstructive sleep apnea; COPD ¼ chronic obstructive pulmonary disease.
*
() = Number of subjects included in meta-analysis if multiple doses of alcohol were compared against placebo in the study.∞ Number of drinks estimated assuming body weight of 70 kg and 14 g alcohol per average drink.