Table 2.

Additional details from included studies

Author and date of Publication	AHI Definition	Changes in Sleep Duration following alcohol use TST (SD) Alcohol Night Placebo Night P value of difference	Differences based on Sleep Stage REM AHIR(SD) NREM AHI N(SD) P value of difference	Differences based on hours following alcohol consumption Hours from sleep onset AHIA/SpO2A alcohol(SD) AHIp/SpO2p placebo(SD) P value of difference
Arnedt et al 2017 30	NA	425.25(42.60) 436.69(31.02) NS	NA	NA
Block et al 1986 19	Apnea: cessation of flow at the nose and mouth for ≥10 s Hypopnea: Decreased flow and chest movement with oxygen desaturation Desaturation was thought to be clinically significant when a decrease of 4 >% from the preceding baseline occurred	319.48 (61.01) 338.31 (70.59) NS	NA	NA
Block et al 1987 20	Apnea: cessation of flow at the nose and mouth for ≥10 s Hypopnea: Decreased flow and chest movement with oxygen desaturation Desaturation was thought to be clinically significant when a decrease of >4% from the preceding baseline occurred	357 (34) 281.5 (59.82) P <0.05	NA	NA
Brander et al 1992 21	No AHI reported	NA	NA	SpO2 was lower in the first 2 h after alcohol consumption*
Collop et al 1994 22	Apnea: cessation of airflow at the mouth and nose for ≥10 s Hypopnea: 50% diminution in airflow accompanied by oxygen desaturation of ≥4%	403.7 (24) 346.1 (75.7) P <0.05	NA	1st 3 hours: AHIA=23.8 (7.7) AHIP=7.37 (1.7) P <0.05
Herzog et al 2004 23	Apnea: 20% reduction to complete cessation of respiratory airflow for >10 s Hypopnea: 50% reduction in airflow	NA	NA	NA
Herzog et al 2004 23	Apnea: cessation of nasal pressure recording for ≥10 s Hypopnea: ≥30% reduction of nasal pressure for ≥10 s with ≥4% desaturation from baseline, with ≥90% of the event’s duration meeting the amplitude reduction criteria for hypopnea	354 (62.5) 354 (65.3) NS
Izumi et al 2005 24	Apnea: >10 second pause in ventilation Hypopnea: ≥30% reduction in airflow	NA	NA	In the latter half of the night: AHIA=5.5(5.5) AHIP=1.3(1.6) P<0.001 In the early half of the night: SpO2A=94.8(1.4) SpO2P=95.7(1.3) P<0.001∞
Kido et al 2016 25	Not Available	482.9 (41.3) 474.1 (38.2) NS	NA	NA
Reimann et al 2010 26	NA	NA	NA	NA
Scanlan et al 2000 27	Apnea: absence of oronasal airflow for >10 s despite continued out-of-phase chest and abdominal movements Hypopnea: reduction in oronasal airflow for >10 s associated with a >2% fall in SpO2 despite continued out-of-phase chest and abdominal movements, increased submental EMG activity, or snoring	399 (8) 400 (11) NS	NA	NA
Scrima et al 1989 10	No AHI reported, only DBEs. Apnea: thermistor tracing indicated cessation of breathing for >10 s accompanied by rhythmical bursts of intercostal EMG activity Hypopnea: discernible decrease but not cessation in ventilation for >10 s, accompanied by increased respiratory effort and a decline in SpO2 to 92% or below	NA	No difference in DBEs in REM and NREM sleep following alcohol consumption compared to placebo	NA
Taasan et al 1981 28	Apnea: cessation of nasal or oral flow ≥ 10 s Hypopnea: desaturation (≥4%) and simultaneous decrease in air flow or chest movement	NA	NA	NA
Teschler et al 1996 29	Apnea: episodes of cessation of airflow lasting >10 s associated with paradoxical movements of the chest wall and abdomen Hypopnea: episodes other than apneas lasting >10 seconds during which the thermistor signal was reduced to <50% of its magnitude during normal unobstructed breathing and SpO2 dropped by ≥4%	320 (6) 333 (5) NS		First 2 hours of the night: AHIA= 41.0(7.8) AHIP= 45.6(6.2) NS

AHI= Apnea hypopnea index NA=Not available NS= Not significant AHI^A=AHI on alcohol night AHI^P=AHI on placebo night SpO2^A=SpO2 on alcohol night SpO2^P=SpO2 on placebo night DBE=disordered breathing events.

^*Numerical values not provided.∞ No significant difference in AHI in the early part of the night and SpO2 in the latter part of the night