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. Author manuscript; available in PMC: 2021 Nov 30.
Published in final edited form as: Stat Med. 2020 May 25;39(27):3897–3913. doi: 10.1002/sim.8564

TABLE 4.

Simulation allowing heritability (h2) to vary by sex: average point estimates (h¯Male2,h¯Female2) across 1000 simulated datasets. In parentheses: true standard error (standard deviation of estimates across all datasets), average estimated standard error, and 95% confidence interval coverage rate. NACE-S and Falconer-S are the traditional NACE/Falconer methods except fit stratified by sex. "Npairs" is the number of twin pairs in each category: MZ male, MZ female, DZ male and DZ female.

Npairs Model h¯Male2=0.60 h¯Female2=0.30
450 NACE-S 0.60 (0.07, 0.07, 0.95) 0.30 (0.07, 0.07, 0.95)
GEE2-NACE 0.60 (0.07, 0.07, 0.96) 0.30 (0.07, 0.07, 0.94)
Falconer-S 0.60 (0.08, 0.06, 0.84) 0.30 (0.08, 0.06, 0.83)
GEE2-Falconer 0.60 (0.08, 0.08, 0.96) 0.30 (0.08, 0.08, 0.95)
100 NACE-S 0.59 (0.14, 0.13, 0.90) 0.31 (0.15, 0.15, 0.96)
GEE2NACE 0.59 (0.15, 0.14, 0.92) 0.31 (0.15, 0.14, 0.94)
Falconer-S 0.60 (0.17, 0.12, 0.82) 0.31 (0.18, 0.12, 0.82)
GEE2-Falconer 0.60 (0.17, 0.16, 0.92) 0.31 (0.17, 0.17, 0.95)