Skip to main content
. 2021 Oct 17;30(3):2069–2079. doi: 10.1007/s00520-021-06619-6

Table 2.

The Changes in Chemotherapy Symptom Assessment Scale According to Paclitaxel Cycles (n = 84)

Variable Status T1 T2 T3 T4 T5 p value Q Difference between end of cure measurements
(n) (%) (n) (%) (n) (%) (n) (%) (n) (%)
Nausea-vomiting before treatment Present 2 2.4 2 2.4 2 2.4 1 1.2 0* 0 p = 0.934 0.429 -
Absent 82 97.6 82 97.6 82 97.6 83 98.8 84 100
Nausea after treatment Present 75 89.3 19 22.6 10 11.9 7 8.3 10 11.9 p < 0.001 188.960

T1-T2 (p < 0.001, Q = 0.667)

T1-T3 (p < 0.001, Q = 0.774)

T1-T4 (p < 0.001, Q = 0.774)

T1-T5 (p < 0.001, Q = 0.810)
Absent 9 10.7 65 77.4 74 88.1 77 91.7 74 88.1
Vomiting after treatment Present 19 22.6 3 3.6 1 1.2 0* 0 0* 0 p < 0.001 29.200

T1-T2 (p < 0.001, Q =  − 0.190)

T1-T3 (p < 0.001, Q =  − 0.214)
Absent 65 77.4 81 96.4 83 98.8 84 100 84 100
Constipation Present 44 52.4 31 36.9 21 25.0 15 17.9 15 17.9 p < 0.001 43.461

T1-T3 (p < 0.001, Q = 0.274)

T1-T4 (p < 0.001, Q = 0.345)

T1-T5 (p < 0.001, Q = 0.345)

T2-T4 (p < 0.001, Q = 0.190)

T2-T5 (p = 0.026, Q = 0.190)
Absent 40 40.7 53 63.1 63 75.0 69 82.1 69 82.1
Diarrhea Present 15 17.9 3 3.6 10 11.9 10 11.9 10 11.9 0.052 9.385 -
Absent 69 82.1 81 96.4 74 88.1 74 88.1 74 88.1
Pain Present 35 41.7 59 70.2 54 64.3 58 69.0 64 76.2 p < 0.001 33.026

T1-T2 (p < 0.001, Q = 0.286)

T1-T3 (p = 0.006, Q = 0.226)

T1-T4 (p < 0.001, Q = 0.274)

T1-T5 (p < 0.001, Q = 0.345)
Absent 49 58.3 25 29.8 30 35.7 26 31.0 20 23.8
Dyspnea Present 5 6.0 6 7.1 6 7.1 6 7.1 6 7.1 0.997 0.154 -
Absent 79 94.0 78 92.9 78 92.9 78 92.9 78 92.9
Signs of infection Present 2 2.4 3 3.6 3 3.6 3 3.6 3 3.6 0.991 0.286 -
Absent 82 97.6 81 96.4 81 96.4 81 96.4 81 96.4
Bleeding or bruising Present 1 1.2 0* 0 2 2.4 0* 0 1 1.2 0.717 0.667 -
Absent 83 98.8 84 100 82 97.6 84 100 83 98.8
Pins and needles in hands, feet Present 24 28.6 20 23.8 38 45.2 57 67.9 74 88.1 p < 0.001 111.957

T1-T4 (p < 0.001, Q = 0.393)

T1-T5 (p < 0.001, Q = 0.595)

T2-T3 (p = 0.003, Q = 0.214)

T2-T4 (p < 0.001, Q = 0.440)

T2-T5 (p < 0.001, Q = 0.643)

T3-T4 (p = 0.018, Q = 0.226)

T3-T5 (p < 0.001, Q = 0.429)

T4-T5 (p < 0.005, Q = 0.202)
Absent 60 71.4 64 76.2 46 54.8 27 32.1 10 11.9
Problems with the skin or nails Present 68 81.0 55 65.5 63 75.0 72 85.7 79 94.0 p < 0.001 30.481

T2-T4 (p = 0.003, Q = 0.202)

T2-T5 (p < 0.001, Q = 0.286)

T3-T5 (p = 0.006, Q = 0.190)
Absent 16 19.0 29 34.5 21 25.0 12 14.3 5 6.0
Hair loss Present 84* 100 0* 0 3 3.6 2 2.4 7 8.3 p = 0.148 3.818 -
Absent 0 0 84 100 81 96.4 82 97.6 77 91.7
Problems with the mouth and throat Present 65 77.4 52 61.9 54 64.3 57 67.9 59 70.2 p = 0.058 9.117 -
Absent 19 22.6 32 38.1 30 35.7 27 32.1 25 29.8
Change in appetite Present 72 85.7 41 48.8 54 64.3 44 52.4 43 51.2 p < 0.001 33.990

T1-T2 (p < 0.001, Q = 0.369)

T1-T3 (p = 0.039, Q = 0.214)

T1-T4 (p < 0.001, Q = 0.333)

T1-T5 (p < 0.001, Q = 0.345)
Absent 12 14.3 43 51.2 30 35.7 40 47.6 41 48.8
Losing or gaining weight Present 50 59.5 12 14.3 34 40.5 32 38.1 37 44.0 p < 0.001 33.368

T1-T2 (p < 0.001, Q = 0.452)

T1-T4 (p < 0.005, Q = 0.214)

T2-T3 (p = 0.004, Q =  − 0.262)

T2-T4 (p = 0.012, Q =  − 0.238)

T2-T5 (p = 0.001, Q =  − 0.298)
Absent 34 40.5 72 85.7 50 59.5 52 61.9 47 56.0
Problems with the eyes Present 51 60.7 7 8.3 15 17.9 16 19.0 29 34.5 p < 0.001 75.139

T1-T2 (p < 0.001, Q = 0.524)

T1-T3 (p < 0.001, Q = 0.429)

T1-T4 (p < 0.001, Q = 0.417)

T1-T5 (p = 0.001, Q = 0.262)

T2-T5 (p = 0.001, Q =  − 0.262)
Absent 33 39.3 77 91.7 69 72.1 68 81.0 55 65.5
Fatigue Present 84* 100 68 81.0 73 86.9 74 88.1 75 89.3 p = 0.332 3.412 -
Absent 0 0 16 19.0 11 13.1 10 11.9 9 10.7
Feeling exceptionally tired Present 66 78.6 10 11.9 20 23.8 10 11.9 20 23.8 p < 0.001 123.529

T1-T2 (p < 0.001, Q =  − 0.655)

T1-T3 (p < 0.001, Q =  − 0.536)

T1-T4 (p < 0.001, Q =  − 0.655)

T1-T5 (p < 0.001, Q =  − 0.536)
Absent 18 21.4 74 88.1 64 76.2 74 88.1 64 76.2
Difficulty sleeping Present 35 41.7 35 41.7 41 48.8 42 50.0 51 60.7 p = 0.016 12.169

T1-T5 (p = 0.027, Q = 0.190)

T2-T5 (p = 0.027, Q = 0.190)
Absent 49 58.3 49 58.3 43 51.2 42 50.0 33 39.3
Headaches Present 48 57.1 26 31.0 40 47.6 30 35.7 32 38.1 p = 0.001 18.491

T1-T2 (p = 0.001, Q = 0.262)

T1-T4 (p = 0.018, Q = 0.214)
Absent 36 42.9 58 69.0 44 52.4 54 64.3 52 61.9
Feeling anxious or troubled Present 61 72.6 47 56.0 44 52.4 48 57.1 43 51.2 p = 0.008 13.673

T1-T3 (p = 0.021, Q =  − 0.202)

T1-T5 (p = 0.011, Q =  − 0.214)
Absent 23 27.4 37 44.0 40 47.6 36 42.9 41 48.8
Feeling pessimistic, upset Present 52 61.9 38 45.2 34 40.5 39 46.4 43 51.2 p = 0.015 12.289 T1-T3 (p = 0.011, Q =  − 0.214)
Absent 32 38.1 46 54.8 50 59.5 45 53.6 41 48.8
Change in sexual life Present 54 64.3 0* 0 5 6.0 5 6.0 1 1.2 p < 0.001 129.542

T1-T3 (p < 0.001, Q = 0.543)

T1-T4 (p < 0.001, Q = 0.583)

T1-T5 (p < 0.001, Q = 0.631)
Absent 30 35.7 84 100 79 94.0 79 94.0 83 98.8
Change in the menstrual cycle Present 46 54.8 1 1.2 2 2.4 1 1.2 1 1.2 p < 0.001 160.280

T1-T2 (p < 0.001, Q =  − 0.536)

T1-T3 (p < 0.001, Q =  − 0.524)

T1-T4 (p < 0.001, Q =  − 0.536)

T1-T5 (p < 0.001, Q =  − 0.536)
Absent 38 45.2 83 98.8 82 97.6 83 98.8 83 98.8

T1, before cure; T2, end of 1st cure; T3, end of 4th cure; T4, end of 8th cure; T5, end of 12th cure; Q, Cochran Q test (Bonferroni Correction)

*Since the value on the boxes is “0,” it could not be included in the statistical analysis