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. 2021 Jul 2;126(10):1296–1311. doi: 10.1007/s11547-021-01389-x

Table 4.

Examples of second-order statistics features evaluated on each matrix with their description [23]

Group of features Type of feature Measure
Gray Level Co-occurrence Matrix (GLCM) Correlation Linear dependency of gray level values to their respective voxels in the GLCM
Difference Entropy a measure of the randomness/variability in neighborhood intensity value differences
Difference Average A measure of the relationship between occurrences of pairs with similar intensity values and occurrences of pairs with differing intensity values
Difference Variance A measure of heterogeneity that places higher weights on differing intensity level pairs that deviate more from the mean
Joint Energy A measure of homogeneous patterns in the image
Joint Entropy A measure of the randomness/variability in neighborhood intensity values
Inverse Difference Moment (IDM), Inverse Difference Moment Normalized (IDMN) and Inverse Difference (ID) A measure of the local homogeneity of an image
Autocorrelation A measure of the magnitude of the fineness and coarseness of texture
Joint Average The mean gray level intensity of the i distribution
Cluster Prominence A measure of the skewness and asymmetry of the GLCM
Cluster Shade A measure of the skewness and uniformity of the GLCM
Cluster Tendency A measure of groupings of voxels with similar gray level values
Contrast A measure of the local intensity variation, favoring values away from the diagonal
Informational Measure of Correlation (IMC) 1 and 2 and Maximal Correlation Coefficient (MCC) A quantification of the complexity of the texture
Maximum Probability Occurrences of the most predominant pair of neighboring intensity values
Sum Average A measure of the relationship between occurrences of pairs with lower intensity values and occurrences of pairs with higher intensity values
Sum Entropy A sum of neighborhood intensity value differences
Sum of Squares A measure in the distribution of neighboring intensity level pairs about the mean intensity level in the GLCM
Gray Level Run Length Matrix (GLRLM) Short Run Emphasis (SRE) A measure of the distribution of short run lengths, with a greater value indicative of shorter run lengths and more fine textural textures
Long Run Emphasis (LRE) A measure of the distribution of long run lengths, with a greater value indicative of longer run lengths and more coarse structural textures
Gray Level Non-Uniformity (GLN) and Gray Level Non-Uniformity Normalized (GLNN) A measure of the similarity of gray level intensity values in the image
Run Length Non-Uniformity (RLN) and Run Length Non-Uniformity Normalized (RLNN) A measure of the similarity of run lengths throughout the image
Run Percentage (RP) A measure of the coarseness of the texture by taking the ratio of number of runs and number of voxels in the ROI
Gray Level Variance (GLV) The variance in gray level intensity for the runs
Run Variance (RV) The variance in runs for the run lengths
Run Entropy (RE) a measure of the uncertainty/randomness in the distribution of run lengths and gray levels
Low and High Gray Level Run Emphasis (LGLRE and HGLRE) A measure of the distribution of low and higher gray level values
Short and Long Run Low Gray Level Emphasis (SRLGLE and LRLGLE) A measure of the joint distribution of shorter and long run lengths with lower gray level values
Short and Long Run High Gray Level Run Emphasis (SRHGLE and LRHGLE) A measure of the joint distribution of shorter and long run lengths with higher gray level values
Gray Level Size Zone Matrix (GLSZM) Small and Large Area Emphasis (SAE and LAE) A measure of the distribution of small and large size zones
Gray Level Non-Uniformity (GLN) and Gray Level Non-Uniformity Normalized (GLNN) A measure of the variability of gray level intensity values in the image
Size Zone Non-Uniformity (SZN) and Size Zone Non-Uniformity Normalized (SZNN) A measure of the variability of size zone volumes in the image
Zone Percentage (ZP) A measure of the coarseness of the texture by taking the ratio of number of zones and number of voxels in the region of interest
Gray Level Variance (GLV) The variance in gray level intensities for the zones
Zone Variance (ZV) The variance in zone size volumes for the zones
Zone Entropy (ZE) A measure of the uncertainty/randomness in the distribution of zone sizes and gray levels
Low and High Gray Level Zone Emphasis (LGLZE and HGLZE) A measure of the distribution of lower and higher gray level size zones
Small Area Low and High Gray Level Emphasis (SALGLE and SAHGLE) A measure of the proportion in the image of the joint distribution of smaller size zones with lower and higher gray level values
Large Area Low and High Gray Level Emphasis (LALGLE and LAHGLE) A measure of the proportion in the image of the joint distribution of larger size zones with lower gray level values
Neighboring Gray Tone Difference Matrix (NGTDM) Coarseness An average difference between the center voxel and its neighborhood and an indication of the spatial rate of change
Contrast A measure of the spatial intensity change, also dependent on the overall gray level dynamic range
Busyness A measure of the change from a pixel to its neighbor
Complexity A measure of non-uniformity and rapid changes in gray levels
Strength A measure of the primitives in an image
Gray Level Dependence Matrix (GLDM) Small and Large Dependence Emphasis (SDE and LDE) A measure of the distribution of small and large dependencies
Gray Level Non-Uniformity (GLN) The similarity of gray level intensity values in the image
Dependence Non-Uniformity (DN) and Dependence Non-Uniformity Normalized (DNN) The similarity of dependence throughout the image
Gray Level Variance The variance in gray level in the image
Dependence Variance the variance in dependence size in the image
Low and High Gray Level Emphasis (LGLE and HGLE) The distribution of low and high gray level values
Small and Large Dependence Low Gray Level Emphasis (SDLGLE and LDLGLE) The joint distribution of small and large dependence with lower gray level values
Small and Large Dependence High Gray Level Emphasis (SDHGLE and LDHGLE) The joint distribution of small and large dependence with higher gray level values