Table 1.
Patients and characteristics of the included studies.
| Author / Year | Intervention | Number of centers | Blinding | Analyses | Duration (mean) | Number of patients (ITT) | Mean age (yrs) | Male (%) | Scale | JADAD score |
|---|---|---|---|---|---|---|---|---|---|---|
| Adli, 2017 [6] | AGT | 10 | No | LOCF | 20w | 429 | 44.2 | 36.83 | HAMD-21 | 3 |
| Alexopoulos, 2009 [35] | CC | 20 | No | OC | 24 m | 599 | NR | 28.38 | HAMD-24 | 2 |
| Aragonès, 2014 [40] | CC | 20 | Single | OC | 12 m | 338 | 47 | 20.12 | PHQ-9 | 2 |
| Bauer, 2009 [11] | MBC | 1 | No | LOCF | 12w | 148 | 48.2 | 40.54 | BRMS | 3 |
| Bosanquet, 2018 [31] | CC | 4 | No | NR | 18 m | 415 | 71.9 | 82.89 | PHQ-9 | 3 |
| Camacho, 2018 [41] | CC | 36 | Single | NR | 24 m | 387 | 58.5 | 62.02 | SCL-D13 | 3 |
| Chaney, 2011 [33] | CC | 10 | No | LOCF | 7 m | 546 | 64.2 | 96.15 | PHQ-9 | 2 |
| Chew-Graham, 2007 [30] | CC | 43 | Single | OC | 16w | 105 | 75.5 | 27.62 | SCL-20 | 3 |
| Ell, 2010 [42] | CC | 2 | No | NR | 18 m | 387 | NR | 17.83 | PHQ-9 | 3 |
| Finley, 2003 [43] | CC | 1 | No | NR | 6 m | 125 | 54.28 | 15.20 | BIDS | 2 |
| Fortney, 2007 [44] | CC | 7 | Single | OC | 12 m | 395 | 59.2 | 91.65 | SCL-20 | 2 |
| Gilbody, 2017 [32] | CC | 32 | Single | NR | 12 m | 705 | 77 | 42.27 | PHQ-9 | 3 |
| Guo, 2015 [13] | MBC | 1 | Single | LOCF | 24w | 120 | 41.1 | 35.83 | HAMD-17 | 3 |
| Harter, 2018 [17] | SCM | 49 | NR | LOCF | 12 m | 737 | 42.1 | 26.59 | PHQ-9 | 3 |
| Huijbregts, 2013 [45] | CC | 18 | Single | OC | 12 m | 150 | 48.67 | NR | PHQ-9 | 3 |
| Hunkeler, 2006 [34] | CC | 18 | Single | OC | 12 m | 1801 | 71.2 | 35.00 | SCL-20 | 2 |
| Katon, 1999 [8] | CC | 4 | Single | NR | 6 m | 228 | 47.8 | 27.70 | SCL-20 | 3 |
| Katon, 2004 [46] | CC | 9 | Single | NR | 12 m | 329 | 58.35 | 35.00 | SCL-90 | 3 |
| Lagomasino, 2017 [36] | CC | 3 | No | OC | 16w | 400 | 49.6 | 16.75 | PHQ-9 | 3 |
| Menchetti, 2013 [37] | CC | 16 | Single | ITT | 12 m | 227 | 51.8 | 23.79 | PHQ-9 | 3 |
| Richards, 2013 [47] | CC | 51 | Single | OC | 12 m | 581 | 44.8 | 28.06 | PHQ-9 | 3 |
| Richards, 2008 [48] | CC | 1 | Single | OC | 3 m | 114 | 42.47 | 22.81 | PHQ-9 | 3 |
| Ricken, 2011 [49] | MBC | 1 | No | OC | 20w | 148 | 48.2 | 40.54 | BRMS | 3 |
| Simon, 2000 [50] | CC | 5 | Single | OC | 6 m | 613 | 46.6 | 17.46 | HSCD-20 | 3 |
| Solberg, 2015 [51] | CC | 75 | No | NR | 6 m | 2348 | 44.4 | 27.30 | PHQ-9 | 2 |
| Unützer, 2002 [16] | CC | 18 | Single | NR | 12 m | 1801 | 71.2 | 35.15 | SCL-20 | 3 |
| Vlasveld, 2012 [52] | MBC | 1 | No | NR | 12 m | 126 | 42.63 | 46.03 | PHQ-9 | 3 |
| Yeung, 2012 [14] | AGT | 74 | Single | ITT | 6 m | 642 | 46 | 33.64 | PHQ-9 | 2 |
| Yoshino, 2009 [15] | AGT | 1 | No | NR | 54 m | 210 | 48.9 | 50.95 | CGI | 2 |
AGT algorithm-guided treatment, BIDS Brief Inventory for Depressive Symptoms, CC collaborative care, HSCD-20 20 item depression scale from the Hopkins symptom checklist, ITT intent-to treat, MBC measurement-based care, NR not report, OC observed cases, SCM stepped care model, which was treated as MBC in this study.