Table 2.
Genotype and allele frequencies distribution in patients with brucellosis and controls
| Model | Genotype | Cases (n = 108) No. (%) | Controls (n = 108) No. (%) | OR (95% CI) | P-value |
|---|---|---|---|---|---|
| MiR-146a rs2910164 | |||||
| Allele | C | 31 (28.7) | 43 (39.8) | 1 | 0.085 |
| G | 77 (71.3) | 65 (60.2) | 1.64 (0.93–2.89) | ||
| Co-dominant | GG | 57 (52.8) | 26 (24.1) | 1.00 | < 0.0001 |
| GC | 40 (37) | 78 (72.2) | 4.27 (2.35–7.79) | ||
| CC | 11 (10.2) | 4 (3.7) | 0.80 (0.23–2.74) | ||
| Dominant | G/G | 57 (52.8) | 26 (24.1) | 1.00 | < 0.0001 |
| GC-CC | 51 (47.2) | 82 (75.9) | 3.52 (1.97–6.30) | ||
| Recessive | GG-GC | 97 (89.8) | 104 (96.3) | 1.00 | 0.056 |
| CC | 11 (10.2) | 4 (3.7) | 0.34 (0.10–1.10) | ||
| MiR-146a rs57095329 | |||||
| Allele | A | 104 (96.3) | 100 (92.6) | 1 | 0.235 |
| G | 4 (3.7) | 8 (7.4) | 2.08 (0.60–7.125) | ||
| Co-dominant | AA | 98 (90.7) | 104 (96.3 | 1.00 | 0.047 |
| AG | 6 (5.6) | 4 (3.7) | 0.63 (0.17–2.29) | ||
| GG | 4 (3.7) | 0 (0) | 0.00 (0.00–NA) | ||
| Dominant | AA | 98 (90.7) | 104 (96.3) | 1.00 | 0.092 |
| AG-GG | 10 (9.3) | 4 (3.7) | 0.38 (0.11–1.24) | ||
| Recessive | AA-AG | 104 (96.3) | 108 (100) | 1.00 | 0.018 |
| GG | 4 (3.7) | 0 (0) | 0.00 (0.00–NA) | ||