Table 1.

List of FDA approved RdRp inhibitors.

S. No.	Name	Viral Infection	Mode of action	References
1.	Remdesivir (Phase 3)	COVID-19, Ebola virus	It terminates the nascent viral RNA chains when interacted with them.	[39, 40]
2.	PSI-7977 (Sofosbuvir)	Hepatitis C virus	Specifically inhibits the hepatitis C NS5B protein, undergoes metabolism intracellularly and forms uridine analog triphosphate (GS-461,203), a pharmacologically active compound.	[41]
3.	Galidesivir	Flavivirus (broad spectrum)	Competes with natural nucleotide at its binding site and changes the conformation of the viral enzyme by altering electrostatic interactions.	[42]
4.	Ribavirin	Hepatitis C virus	The metabolite ribavirin as ribavirin triphosphate (RTP) inhibits viral mRNA polymerase.	[43]
5.	Favipiravir	Influenza	Phosphorylated favipiravir interferes with nascent RNA strand, and stops the elongation of RNA strand and prevents proliferation of virus.	[44]
6.	Dasabuvir	Hepatitis C virus	Binds with NS5B polymerase in the palm domain and brings the structural changes which stops further extension of the viral genome.	[43]