FIGURE 1.

p16‐RFP expression is increased in the brain of aged p16‐3MR mice and abundantly express inflammatory and microglia genes. (a) Mean fluorescent RFP intensity of all viable cells in young compared to old brains. ****p<0,0001. (b) Percentage of viable cells positive for RFP in young mouse brains compared to old. ****p<0,0001. (c) PCA plot of bulk sequenced RFP^Low and RFP^High cells from old mouse brains. (d) Heatmap of all differentially expressed gene between the RFP^Low and RFP^High samples. E: Expression and gene‐ontology analysis of a WGCNA module enriched in RFP^High samples