FIGURE 3.
Increased expression of p16 in mouse and human microglia. (a) Gene expression of cell marker genes in RFPLow compared to RFPHigh mouse samples. (b) Barplot showing the distribution of cells types in the mouse CNS bulk dataset after deconvolution. (c) p16 expression measured by qPCR in cells isolated from young and old mouse brains. ****p<0,0001. (d) CCKN2A expression in human microglia and total cortical tissue (from Galatro et al., 2017). ****p<0,0001E: UMAP depicting CDKN2A expression in 450,000 CNS cell nuclei (Gerrits et al. 2021)