Kuzemko 1972 |
Anticonvulsants used (chloral hydrate and diazepam) were not agents of interest in the current meta‐analysis |
Ruth 1988 |
Randomized premature, very low birth weight infants to receive phenobarbital or placebo following birth; perinatal asphyxia was not an eligibility criterion |
Srinivasakumar 2015 |
Randomized controlled trial evaluating the impact of treating electrographic seizures in hypoxic ischemic encephalopathy. Neonates ≥ 36 weeks' gestation with moderate or severe hypoxic ischemic encephalopathy were randomly assigned to either treatment of electrographic seizures alone or treatment of clinical seizures. Conventional electroencephalography video was monitored in both groups for up to 96 hours. Cumulative electrographic seizure burden was calculated in seconds and converted to log units for analysis. Magnetic resonance imaging scans were scored for severity of brain injury. Infants underwent neurodevelopmental evaluation at 18‐24 months |
van Rooij 2010 |
Randomized infants to receive treatment (not prophylaxis) for both clinical and subclinical seizures compared to blinding of amplitude‐integrated electroencephalography registration and treatment of clinical seizures only |
Wilkinson 1989 |
Anticonvulsants were used for treatment (not prevention) of electroencephalographically apparent seizures of any etiology, not exclusively perinatal asphyxia. Infants were a mixture of term and premature neonates. It was not possible to extract the data relating only to term infants following asphyxia |