. 2021 Oct 4;12:716500. doi: 10.3389/fneur.2021.716500

Table 3.

Functional connectivity differences between TN patients and healthy controls, and responders and non-responders to surgical treatment for TN.

Connectivity difference	Seed region	Connection	T -value	P -value (raw)	P -value (FDR adjusted)
TN vs. Healthy controls
Increased connectivity	Thalamus (left)	Insular cortex (right)	t₍₃₉₎ = 3.67	p = 0.0007^*	0.0065^*
Increased connectivity	Thalamus (right)	Insular cortex (right)	t₍₃₉₎ = 3.22	p = 0.0026^*	0.0117^*
Non-responders vs. Responders
Increased connectivity	Hippocampus (left)	Hippocampus (right)	t₍₁₈₎ = 2.85	p = 0.0106^*	0.0477^*
Decreased connectivity	ACC	Amygdala (left)	t₍₁₈₎ = −2.94	p = 0.0087^*	0.0392^*
Decreased connectivity	ACC	Hippocampus (right)	t₍₁₈₎ = −3.20	p = 0.0049^*	0.0392^*

TN patients vs. healthy controls: patients with TN show increased resting-state functional connectivity between the thalamus (both left and right) and right insula. Responders vs. Non-responders: non-responders show increased resting-state functional connectivity between the left and right hippocampus. Non-responders also show decreased resting-state functional connectivity between the anterior cingulate cortex and left amygdala and right hippocampus. Two-sample Student's t-test used with false-discovery rate (FDR) correction. Threshold for statistical significance was set at ^*p < 0.05. ACC, anterior cingulate cortex.