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. 2021 Oct 4;12:750397. doi: 10.3389/fphar.2021.750397

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Copyright © 2021 Meng, Yan, Liu, Gong, Tian, Wu, Sun, Shi, Lu, Yuan and Xue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Social interaction with relapsed partners triggered relapse in cocaine CPP model. (A) Experimental timeline. (B–E) All rats obtained cocaine CPP training and extinction. (B) Cocaine injection triggered relapse of the partners, and social interaction with relapsed partner enhanced drug seeking of targeted rats. (C) No social interaction had no influence on relapse of targeted rats. (D) Social interaction with unrelapsed partner had no effect on relapse of targeted rats. (E) Social interaction with relapsed stranger had no effect on relapse of targeted rats. (Data are shown as mean ± SEM. *p < 0.05, compared with extinction test. n = 6–7).