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. 2021 Oct 4;8:693959. doi: 10.3389/fmed.2021.693959

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Copyright © 2021 Li, Wang, Zhang, Fan, Li, Zhou, Yang, Shi, Li, Zhang, Chen and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Internal validation of the five-FRGs signature. Distribution of IPF samples (A) and OS status (B) based on the median value of the risk scores. PCA (C) and t-SNE (D) analysis of the testing group. Kaplan–Meier survival (E) and time-dependent ROC curve (F) analysis of the five-FRGs signature in the testing group. (G) Heatmap of the expression profiles of the five-FRGs in low- and high-risk groups of the testing cohort. FRGs, ferroptosis-related genes; IPF, idiopathic pulmonary fibrosis; OS, overall survival; PCA, principal component analysis; t-SNE, t-distributed stochastic neighbor embedding; ROC, receiver operating characteristic.