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. 2021 Oct 4;9:729076. doi: 10.3389/fcell.2021.729076

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Copyright © 2021 Zhang, Ben Zablah, Zhang and Jia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Rho GTPases in AMPAR expression, LTP and LTD. RhoA, Cdc42, and Rac1 can participate in the regulation of the synaptic insertion, internalization and membrane stability of AMPARs during LTP and LTD. These GPTases are activated by NMDARs or other surface proteins through various GAPs and GEFs.