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. 2021 Oct 4;9:700553. doi: 10.3389/fcell.2021.700553

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Copyright © 2021 Yu, Ma, Tian, Zhang, Ding, Liu, Yang, Hu, Xuan, Zhou, Wang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Functional enrichment analysis of the 20 differentially expressed IRGs. (A–D) Gene ontology (GO) analysis showed that the differentially expressed genes (DEGs) were closely associated with biological processes such as responses to metal ion, response to cadmium ion, growth hormone receptor complex, collagen trimer, and peptide binding. (E,F) Kyoto encyclopedia of genes and genomes (KEGG) functional analysis suggested that differentially expressed immune genes mainly affected the IL-17, endocrine resistance, TNF and estrogen signaling pathways. (G,H) Detailed demonstrations of the IL-17 and endocrine resistance pathways.