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. 2021 Oct 4;9:700553. doi: 10.3389/fcell.2021.700553

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Copyright © 2021 Yu, Ma, Tian, Zhang, Ding, Liu, Yang, Hu, Xuan, Zhou, Wang and Han.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a clinical prognostic model for patients with hepatocellular carcinoma (HCC). (A,B) Risk factor correlation diagram of the differentially expressed immune-related genes (IRGs). (C) A nomogram was constructed by combining the expression level of MMP9 with clinicopathological features. (D) Calibration curves of the nomogram constructed using the MMP9 gene; the horizontal coordinates are the survival statistics predicted by the nomogram and the vertical coordinates are the actual observed survival situation, each curve was repeated 1,000 times. The curves showed that the nomogram had a good ability to predict prognosis of patients at 1-, 2-, and 3-year. (E) A nomogram was constructed by ESR1 expression with clinicopathological features. (F) Calibration curve of the nomogram constructed using the ESR1 gene. (G,H) Decision curve analysis (DCA) of the nomograms.