TABLE 2.

Statistical analyses of plaque quantification on Congo red–stained brain slices from APPswe/PS1ΔE9 (APP/PS, 24 months) and ARTE10 mice of different ages (9–21 months).

	Plaque	Plaque	Plaque
	load	count	size
Cortex
APP/PS vs. ARTE10 9 months	0.7024	0.3713	0.0049*
APP/PS vs. ARTE10 15 months	0.0003**	0.0027*	< 0.0001***
APP/PS vs. ARTE10 21 months	< 0.0001***	< 0.0001***	< 0.0001***
ARTE10 9 months vs. ARTE10 15 months	0.0007**	0.0002**	0.0074*
ARTE10 9 months vs. ARTE10 21 months	< 0.0001***	< 0.0001***	< 0.0001***
ARTE10 15 months vs. ARTE10 21 months	< 0.0001***	0.0013*	< 0.0001***
Hippocampus
APP/PS vs. ARTE10 9 months	0.1876	0.1943	0.3144
APP/PS vs. ARTE10 15 months	< 0.0001***	< 0.0001***	0.0025*
APP/PS vs. ARTE10 21 months	< 0.0001***	< 0.0001***	< 0.0001***
ARTE10 9 months vs. ARTE10 15 months	< 0.0001***	0.0001**	0.0235*
ARTE10 9 months vs. ARTE10 21 months	< 0.0001***	< 0.0001***	< 0.0001***
ARTE10 15 months vs. ARTE10 21 months	< 0.0001***	0.01*	< 0.0001***
Cerebellum
APP/PS vs. ARTE10 9 months	< 0.0001***	< 0.0001***	NA
APP/PS vs. ARTE10 15 months	< 0.0001***	< 0.0001***	NA
APP/PS vs. ARTE10 21 months	< 0.0001***	< 0.0001***	NA
ARTE10 9 months vs. ARTE10 15 months	0.6609	0.9848	NA
ARTE10 9 months vs. ARTE10 21 months	0.7705	0.6641	NA
ARTE10 15 months vs. ARTE10 21 months	0.8864	0.6876	NA
Brain stem
APP/PS vs. ARTE10 9 months	0.09	0.1008	NA
APP/PS vs. ARTE10 15 months	0.0041*	0.0009**	NA
APP/PS vs. ARTE10 21 months	< 0.0001***	< 0.0001***	NA
ARTE10 9 months vs. ARTE10 15 months	0.1469	0.0385*	NA
ARTE10 9 months vs. ARTE10 21 months	< 0.0001***	< 0.0001***	NA
ARTE10 15 months vs. ARTE10 21 months	< 0.0001***	0.0001**	NA

Shown are results of ANOVA post hoc analysis by Fisher multiple comparisons.

^*p < 0.05, ^**p < 0.001, ^***p < 0.0001.

NA, not analyzed.