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. 2021 Oct 4;15:736891. doi: 10.3389/fnins.2021.736891

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Copyright © 2021 Shen, Zhang, Cho, Li, Zhang, Xie, Wang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MRI-based OEF and DCE perfusion images in representative glioma patients with and without IDH mutation. Two exemplary patients with IDH1-wt (astrocytoma II; A₁–F₁) and IDH1-mut (astrocytoma II; A₂–F₂) lower-grade glioma shown: (A₁) gadolinium contrast-enhanced (GdCE) 3DT1BRAVO, (B₁) T2-FLAIR, (C₁) QQ-based OEF maps by CAT, DCE-MRI with separated K^trans (D₁), CBV (E₁), and CBF (F₁) maps. OEF map (C₁) allows to delineate significantly inhomogeneous hyperintensity in the contrast-enhanced region of the IDH1 wild-type astrocytoma; DCE-derived maps (D₁–F₁) clearly show the area of hyperperfusion and high permeability in the IDH1 wild-type astrocytoma.