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. 2021 Oct 4;15:736891. doi: 10.3389/fnins.2021.736891

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Copyright © 2021 Shen, Zhang, Cho, Li, Zhang, Xie, Wang and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative MRI-based OEF and DCE perfusion images of glioma patients with and without methylated MGMT promoter. Two GBM patients with unmethylated (51-year-old woman with MGMT^–: A₁–F₁) and methylated (58-year-old man MGMT⁺: A₂–F₂) promoter shown: (A₁) GDCE 3D T1BRAVO, (B₁) T2-FLAIR, (C₁) QQ-based OEF maps with CAT, DCE-MRI with separated K^trans (D₁), CBV (E₁), and CBF (F₁) maps. OEF map (C₁) allows to identify a focal area of higher values within the lesion for patients with unmethylated MGMT promoter; DCE-derived maps (D₁–F₁) show a tendency toward higher signal intensities.