TABLE 2.
Comparison of biomarkers for subgroups of IDH mutation status.
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Patients with LGG (WHO II and III)
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| Parameter | IDH mut (mean ± SD) | IDH wt (mean ± SD) | FDR-adjusted p-value |
| OEF (%) | 17.67 ± 4.98 | 23.71 ± 5.50 | 0.001 † |
| Ktrans (mL/min) | 0.04 ± 0.03 | 0.08 ± 0.05 | 0.004 ‡ |
| CBV (mL/100 g) | 1.97 ± 1.40 | 4.35 ± 2.33 | 0.002 ‡ |
| CBF (mL/100 g per min) | 159.90 ± 83.66 | 276.34 ± 116.83 | 0.006 ‡ |
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Patients with GBM (WHO IV)
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| Parameter | IDH mut (mean ± SD) | IDH wt (mean ± SD) | FDR-adjusted p-value |
|
| |||
| OEF (%) | 23.39 ± 6.77 | 23.69 ± 5.52 | 0.645‡ |
| Ktrans (mL/min) | 0.08 ± 0.05 | 0.10 ± 0.06 | 0.494‡ |
| CBV (mL/100 g) | 3.79 ± 2.14 | 5.12 ± 2.97 | 0.420‡ |
| CBF (mL/100 g per min) | 285.85 ± 63.34 | 321.46 ± 173.86 | 0.707‡ |
OEF, oxygen extraction fraction; Ktrans, volume transfer constant; CBV, cerebral blood volume; CBF, cerebral blood flow.
p-values were calculated using Student t-test† or Wilcoxon rank-sum test‡ with false discovery rate (FDR) correction (<0.05). Statistically significant p-values are highlighted in bold font.