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The antidepressant effects of psychoplastogens (e.g., ketamine and psilocybin) are more rapid and sustained than those of traditional antidepressants (e.g., fluoxetine). Data adapted from three clinical trials evaluating the effects of fluoxetine (6), ketamine (7), and psilocybin (8) for treating depression. Dashed lines represent the efficacy of either 1 or 8 weeks of fluoxetine treatment.
