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The joint analysis flowchart to comprehensively investigate the causal relationship between hypothyroidism and PBC. IVW, inverse variance weighted method; LD, linkage disequilibrium; MR, Mendelian randomization; MRPRESSO, Mendelian randomization pleiotropy residual sum and outlier; MR-RAPS, Mendelian randomization robust adjusted profile score; PBC, primary biliary cirrhosis.
