TABLE 1.

GWAS datasets used in the present study.

Trait	Sample size	Description
Hypothyroidism	289,307 individuals of European descent, including 18,740 hypothyroidism cases and 270,567 controls	Data was from the UK Biobank. Hypothyroidism was defined as self-reported history of hypothyroidism/myxoedema
PBC	13,239 individuals of European descent, including 2,764 PBC cases and 10,475 controls	Data was from a GWAS meta-analysis, which integrated samples from three cohorts: Canadian-US cohort including 499 cases and 4,374 controls, the Italian cohort including 449 cases and 940 controls, the UK cohort including 1,816 cases and 5,161 controls. All PBC cases fulfilled the American Association for the Study of Liver disease criteria for PBC.

PBC, primary biliary cirrhosis.