TABLE 2.

The shared loci between hypothyroidism and PBC identified by colocalization analysis.

Region	N_SNPs	PP.H4.abf (%)	Hypothyroidism p-value	Hypothyroidism SNP	PBC p-value	PBC SNP	Best causal
chr2:162,910,536–163,310,536	71	78.6	4.47 × 10−16	rs2111485	7.93 × 10−4	rs2111485	rs2111485
chr17:7,026,957–7,426,957	166	78.0	1.71 × 10−10	rs35776863	1.03 × 10−3	rs35776863	rs35776863

Best causal, the SNP with the highest posterior probability to be the causal variant in the genomic region; Hypothyroidism P-value and Hypothyroidism SNP, the lowest p-value found for hypothyroidism and the corresponding SNP; N_SNPs, the number of SNPs tested in the genomic region; PBC p-value and PBC SNP, the lowest p-value found for PBC and the corresponding SNP; PP.H4.abf, the posterior probability of hypothyroidism and PBC sharing a causal variant; Region, genomic region including chromosome and the start and stop position.